Breast Cancer & Bacteria
For more information about the breast cancer & bacteria study, check out www.rush.edu/rumc.

Doctors have a gut feeling about breast cancer beginning in the intestines. Bacteria there may be the key to breeding breast tumors.

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Nurse: "She is receiving Taxol 124 mg over one hour."

Annie Davis is doing what she has to to be cancer free. On this day getting stuck again for chemo.

Nurse: "Any of these tender at all?"

But before the breast cancer therapy goes into her veins, Annie underwent another procedure ... a colonoscopy. During the test, doctors took samples.

Annie Davis, Breast Cancer Patient: "I said this might turn out to be something good for someone, somewhere along the line. It doesn't have to be directly for me but it's helped me too."

The idea that she might help scientists understand a root cause of breast cancer gives this retired school teacher solace as she sits for treatment. She wonders in her gut if they are not onto something interesting.

Dr. Ece Mutlu, Rush University Medical Center Gastroenterologist: "We are studying the different kinds of bacteria in the gut and trying to indentify their metabolism and relation to disease."

The so-called good bacteria produce vitamins, metabolize food and circulate hormones including estrogen in the body.

Dr. Mutlu: "What we are trying to show or trying to test is that the changes in the diet affect the bacteria and the bacteria in turn affects the re-circulation of estrogen in the body."

Fatty diets and an abundance of estrogen are both linked to breast cancer ... perhaps both beginning in the intestines.

Dr. Mutlu: "If a person has a set of bacteria or bacterial genes that enhance the absorbtion of estrogen in the body then the load of estrogen in the body would be higher and the person would have a higher risk of getting breast cancer."

Bacteria can be passed from mother to daughter ... much like gene mutations for breast cancer.

Dr. Mutlu: "We are trying to study that maybe some of the genes that we pass on with the bacteria from the mother to a daughter could be playing a role in breast cancer by changing estrogen metabolism in the body."

If the cause and effect is shown, doctors may be able to regulate bacteria to prevent certain breast cancers. An exciting idea beginning at the study phase at Rush University Medical Center.